Therapeutic opportunities through modulation of the endocannabinoid system
نویسندگان
چکیده
منابع مشابه
Therapeutic opportunities through modulation of the endocannabinoid system.
The discovery of the cannabinoid receptors and endocannabinoid ligands has generated a great deal of interest in identifying opportunities for the development of novel cannabinergic therapeutic drugs. Such an effort was first undertaken three decades ago by a number of pharmaceutical industries, but was rewarded with only modest success. However, the newly acquired knowledge on the physiologica...
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The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), a group of endogenous neuromodulatory lipids (endocannabinoids), and the machinery for their biosynthesis, metabolism, and transit that are involved in a variety of physiological processes including pain, appetite, memory, inflammatory and immune responses. In the brain, endocannabinoids are primarily involved in re...
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The active principle in marijuana, Delta(9)-tetrahydrocannabinol (THC), has been shown to have wide therapeutic application for a number of important medical conditions, including pain, anxiety, glaucoma, nausea, emesis, muscle spasms, and wasting diseases. Delta(9)-THC binds to and activates two known cannabinoid receptors found in mammalian tissue, CB1 and CB2. The development of cannabinoid-...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2005
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2005.03.012